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  Indian J Med Microbiol
 

Figure 5: Diosmetin ameliorated IMQ-induced psoriasis-like skin lesion in mice (a) Diosmetin ameliorated the pathological changes in skin lesions of IMQ-induced mice, and attenuated IMQ-induced increase of PASI score in mice. (b) Diosmetin ameliorated histopathological analysis in IMQ-induced mice. (c) Diosmetin attenuated IMQ-induced increase of IL-6 and IL-8 mRNA expression in mice. (d) Diosmetin attenuated IMQ-induced increase of IL-6 and IL-8 protein expression in mice. (e) Diosmetin reduced protein expression of Bcl-2, and enhanced Bax and cleaved caspase-3 in IMQ-induced mice. ** P < 0.01. IMQ: Imiquimod.

Figure 5: Diosmetin ameliorated IMQ-induced psoriasis-like skin lesion in mice (a) Diosmetin ameliorated the pathological changes in skin lesions of IMQ-induced mice, and attenuated IMQ-induced increase of PASI score in mice. (b) Diosmetin ameliorated histopathological analysis in IMQ-induced mice. (c) Diosmetin attenuated IMQ-induced increase of IL-6 and IL-8 mRNA expression in mice. (d) Diosmetin attenuated IMQ-induced increase of IL-6 and IL-8 protein expression in mice. (e) Diosmetin reduced protein expression of Bcl-2, and enhanced Bax and cleaved caspase-3 in IMQ-induced mice. ** <i>P</i> < 0.01. IMQ: Imiquimod.