Figure 1: Clinical features of AiKDs. (a) GPP: Sterile pustules on an erythematous lesion on the leg of a patient with a heterozygous IL36RN loss-of-function variant.(b) PRP: Hyperkeratotic erythema on the arm and trunk of a patient with a heterozygous CARD14 gain-of-function variant.(c) Hidradenitis suppurativa: Multiple abscesses with pustular drainage and scars on the axilla and back of a patient with a heterozygous NCSTN loss-of-function variant.(d) Porokeratosis: Typical lesions of disseminated superficial porokeratosis and reddish papules on erythematous lesions on the thigh of a patient with eruptive pruritic papular porokeratosis with a germline MVD loss-of-function variant. AiKD: Autoinflammatory keratinization disease, GPP: Generalized pustular psoriasis, PRP: Pityriasis rubra pilaris.