Close
  Indian J Med Microbiol
 

Figure 3: New potential pathophysiology of skin microbiome in rosacea, modified from Kim and Holmes.[57],[58] TLR-2 and NLRP3 can be are upregulated and activated by Demodex spp. in rosacea patients. Bacillus oleronius can induce the expressions of MMP-9, TNF, and IL-8 by leukocytes chemotaxis. NLRP: Nucleotide-binding oligomerization domain, LRP: Leucine-rich repeat and pyrin domain containing, PAR: Protease-activated receptor, TLR: Toll-like receptor, AMP: Antimicrobial peptide, IL: Interleukin, KLK: Kallikrein, LL-37: Activated cathelicidin, MMP: Matrix metalloproteinase, TNF: Tumor necrosis factor.

Figure 3: New potential pathophysiology of skin microbiome in rosacea, modified from Kim and Holmes.<sup>[57],[58]</sup> TLR-2 and NLRP3 can be are upregulated and activated by <i>Demodex </i>spp. in rosacea patients. <i>Bacillus oleronius</i> can induce the expressions of MMP-9, TNF, and IL-8 by leukocytes chemotaxis. NLRP: Nucleotide-binding oligomerization domain, LRP: Leucine-rich repeat and pyrin domain containing, PAR: Protease-activated receptor, TLR: Toll-like receptor, AMP: Antimicrobial peptide, IL: Interleukin, KLK: Kallikrein, LL-37: Activated cathelicidin, MMP: Matrix metalloproteinase, TNF: Tumor necrosis factor.