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  Indian J Med Microbiol
 

Figure 1: Prenatal infection with lipopolysaccharide or polyinosinic:polycytidylic acid enhances imiquimod-induced epidermal hyperplasia in mice offspring. imiquimod and Vaseline was applied to both ears of mice offspring for 5 consecutive days, and ear thickness was measured daily. (a-c) showed ear thickness change of lipopolysaccharide, polyinosinic:polycytidylic acid, and phosphate-buffered saline groups, respectively. Imiquimod-induced prominent ear swelling as compared with Vaseline in all three groups. (d) showed that there was no significant difference in imiquimod-induced ear swelling among the three groups. The thickness of the epidermis was measured under microscopic view, and (e) showed that both lipopolysaccharide and polyinosinic:polycytidylic acid groups had thicker epidermis than phosphate-buffered saline controls after the 5-day imiquimod application. Representative photos were shown in (f). LPS: Lipopolysaccharide. Poly I:C: Polyinosinic:polycytidylic acid, PBS: Phosphate-buffered saline, IMQ: Imiquimod, *: P < 0.05, **: P < 0.01, ***: P < 0.001, ****: P < 0.0001.

Figure 1: Prenatal infection with lipopolysaccharide or polyinosinic:polycytidylic acid enhances imiquimod-induced epidermal hyperplasia in mice offspring. imiquimod and Vaseline was applied to both ears of mice offspring for 5 consecutive days, and ear thickness was measured daily. (a-c) showed ear thickness change of lipopolysaccharide, polyinosinic:polycytidylic acid, and phosphate-buffered saline groups, respectively. Imiquimod-induced prominent ear swelling as compared with Vaseline in all three groups. (d) showed that there was no significant difference in imiquimod-induced ear swelling among the three groups. The thickness of the epidermis was measured under microscopic view, and (e) showed that both lipopolysaccharide and polyinosinic:polycytidylic acid groups had thicker epidermis than phosphate-buffered saline controls after the 5-day imiquimod application. Representative photos were shown in (f). LPS: Lipopolysaccharide. Poly I:C: Polyinosinic:polycytidylic acid, PBS: Phosphate-buffered saline, IMQ: Imiquimod, *: <i>P</i> < 0.05, **: <i>P</i> < 0.01, ***: <i>P</i> < 0.001, ****: <i>P</i> < 0.0001.