Figure 2: Histopathological examination of the biopsy specimens; (a) from the hyperkeratotic plaque, including the hyperpigmented macule on the sole showed suprapapillary thinning accompanied by hyperkeratosis, parakeratosis, psoriasiform hyperplasia, (b) and increased pigmentation in basal keratinocytes, (c and d) from the lip showed increased pigmentation in basal keratinocytes and an increase in melanophages in the papillary dermis (H and E, original magnification: a ×100, b ×1000, c ×200, d ×400) (The image in Figure 2b is a higher magnification of the area demarcated by the rectangle in Figure 2a).