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  Indian J Med Microbiol
 

Figure 2: Mixed cryoglobulinemia. A 75-year-old male patient had incidental finding of occult hepatitis B virus infection during admission at nephrology ward for survey of cryglobulinemia. He had negative HBsAg but detectable hepatitis B virus viral load. Multiple palpable purpuras developed on the lower legs, dorsal feet and toes. The findings of a skin biopsy were consistent with cryoglobulinemia. Direct immunofluorescence study of the skin specimen revealed vascular staining of IgG, IgA, IgM and C3. Tests of rheumatoid factors, plasma and serum cryoproteins all showed positive results

Figure 2: Mixed cryoglobulinemia. A 75-year-old male patient had incidental finding of occult hepatitis B virus infection during admission at nephrology ward for survey of cryglobulinemia. He had negative HBsAg but detectable hepatitis B virus viral load. Multiple palpable purpuras developed on the lower legs, dorsal feet and toes. The findings of a skin biopsy were consistent with cryoglobulinemia. Direct immunofluorescence study of the skin specimen revealed vascular staining of IgG, IgA, IgM and C3. Tests of rheumatoid factors, plasma and serum cryoproteins all showed positive results