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  Citation statistics : Table of Contents
   2021| October-December  | Volume 39 | Issue 4  
    Online since December 29, 2021

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Taiwan dermatological association recommendations for coronavirus disease of 2019 vaccination in patients treated with immunotherapeutics
Chih-Hung Lee, Yu-Huei Huang, Chia-Yu Chu
October-December 2021, 39(4):169-174
This article aims to present current COVID-19 vaccination considerations for patients on immunotherapeutics for the management of immune-mediated dermatological diseases and summarize the recommendations relevant to clinical practice in Taiwan. These Taiwan Dermatological Association (TDA) recommendations are intended to be dynamic in nature and serve as an interim guide to optimize patient care at this current juncture. It is expected that our clinical practice would continually evolve and be informed by new evidence that emerges in this pandemic.
  3 2,420 281
Hair loss and COVID-19
Kai-Che Wei, Chao-Chun Yang
October-December 2021, 39(4):167-168
  1 4,103 419
Circulating follicular T-helper cells in patients with nonsegmental vitiligo
Ghada Fawzy Rezk Hassan, MennatAllah Mohammed Abdel-Dayem, Mohammed Attia Saad, Doaa Salah Hegab
October-December 2021, 39(4):198-201
Vitiligo is a common depigmenting dermatosis with an autoimmune background. Circulating T-follicular helper (Tfh) cells are reported to increase and correlate with disease activity and autoantibody production in several human autoimmune diseases. The potential contribution of Tfh cells in vitiligo pathogenesis has not been well elucidated yet. Hence, this study aimed to evaluate the frequency of circulating Tfh cells in patients with nonsegmental vitiligo (NSV) in comparison to normal healthy subjects to detect their possible role in vitiligo pathogenesis. Venous blood samples were obtained from 25 patients with NSV and 20 age- and sex-matched healthy controls to determine the level of circulating Tfh cells (CD3+ CD4+ CXCR5+ PD-1+ T cell population), by flowcytometry. The frequency of peripheral CXCR5+ PD-1+ lymphocytes which are CD3+ CD4+ was significantly augmented in vitiligo patients than controls. It showed a significant positive correlation with vitiligo disease severity and activity estimated by Vitiligo Area Scoring Index and Vitiligo Disease Activity scores, respectively. These results emphasize on the potential role of Tfh cells in the pathogenesis, extent, and severity of NSV. Antagonizing the autoimmune initiating action of Tfh cells population or targeting their cytokine secretion might offer a helpful future tool for the treatment of patients with NSV particularly in active cases.
  - 1,555 178
Calcified angioleiomyoma – Histopathologic and ultrasonographic analysis of the calcification process
Ming-Hsiu Hsieh, Miki Izumi, Yukio Nakatani, Kuniaki Ohara
October-December 2021, 39(4):202-205
Historically, angioleiomyoma is a subtype of leiomyoma that comprises about 4%–5% of all benign soft tissue tumors, and calcifications occur in 2%–3% of them. Because of the very low incidence of calcifications, their mechanism of formation is still unknown. In this article, we present the five cases of angioleiomyomas with calcification and discuss the ultrasonographic features in three of those cases. In general, from the aspect of ultrasonography, angioleiomyomas are recognized as hypoechogenic homogenous structures with peritumoral or intratumoral vascularity. However, our cases revealed heterogeneity or hyperechogenicity in inclusions, which has never been reported before. Histologically, calcifications were found not only under the dystrophic pathway which were considered in the past literature but also have the possibility under the metastatic pathway. According to our findings, we also classified the ultrasonographic patterns into three patterns according to the progression and distribution of calcifications. This is the first report to identify the location and possible pathways of calcifications and to classify the ultrasonographic features of calcified angioleiomyomas.
  - 1,138 195
Sweet's syndrome occurred in a case with tuberculous cervical lymphadenitis
Chieh-Hsun Chen, Ting-Ya Yang, Feng-Jie Lai
October-December 2021, 39(4):206-207
  - 1,705 218
Psoriasis flare following ChAdOx1-S/nCoV-19 vaccination in patients with psoriasis under biologic treatment
Jen-Ping Chao, Tsen-Fang Tsai
October-December 2021, 39(4):208-209
  - 2,237 271
A patient with lichen striatus-like eruption following intravenous contrast injection
Li-Wen Chiu, Yue-Chiu Su, Stephen Chu-Sung Hu
October-December 2021, 39(4):210-211
  - 1,858 193
Lymphomatoid papulosis with DUSP22-IRF4 rearrangement on 6p25-3: A case report
Yi-Ning Mao, Jie-Yang Jhuang, Bo-Jung Chen, Yu-Hung Wu
October-December 2021, 39(4):212-213
  - 2,188 205
Carcinoma erysipeloides deriving from a metastatic eccrine porocarcinoma: A rare case report and brief review of the literature
Flandiana Yogianti, Yohanes Ridora, Sunardi Radiono
October-December 2021, 39(4):214-215
  - 1,568 189
Demodex folliculitis of the scalp successfully treated with topical ivermectin
Wei-Cheng Fang, Stephen Chu-Sung Hu
October-December 2021, 39(4):216-217
  - 15,719 325
Successful treatment of disseminated cutaneous lesions of classic type Kaposi sarcoma with low-dose peginterferon alfa-2a: A case report
Wei-Ting Liu, Chaw-Ning Lee, Yin-Yu Ho, Hsiang-Ying Lu, Chia-Jui Yen, Tak-Wah Wong
October-December 2021, 39(4):218-219
  - 1,614 227
Squamous cell carcinoma of the auricle treated by intra-arterial infusion chemotherapy
Yen-Ting Sheen, Yi-Shuan Sheen, Yu-Yuan Chen, Maw-Chang Sheen, Ming-Hsien Lin
October-December 2021, 39(4):220-221
  - 1,512 181
Squamoid eccrine ductal carcinoma: A report of two cases
Jen-Hao Hsu, Chia-Hsiang Chung, Jen-Yu Wang, Yu-Hung Wu, Pa-Fan Hsiao
October-December 2021, 39(4):222-223
  - 1,471 203
Successful treatment of metastatic Crohn disease with dapsone
Yu-Hao Chen, Chao-Kuei Juan, Chung-Hao Hsu, Chung-Yang Yen
October-December 2021, 39(4):224-225
  - 1,750 200
Bacteria-related pigmented clear cell acanthosis of the nipple and areola
Chia-Shuen Lin, Ro-Wei Wu, Chung-Hsing Chang
October-December 2021, 39(4):226-227
  - 1,383 189
Plasmacytoid dendritic cells diminution in peripheral blood is prevalent in drug reaction with eosinophilia and systemic symptoms and may precede human herpesvirus 6 reactivation
Shao-Hsuan Hsu, Che-Wen Yang, Yi-Chun Hsieh, Kai-Lung Chen, Yung-Tsu Cho, Jau-Yu Liau, Chia-Yu Chu
October-December 2021, 39(4):175-181
Background: Plasmacytoid dendritic cells (pDCs) are implicated in the reactivation of human herpesvirus 6 (HHV-6) in drug reaction with eosinophilia and systemic symptoms (DRESS). Objectives: We aimed at identifying the alterations of circulating pDCs, basophils, and myeloid dendritic cells (mDCs) during the active stage of drug eruptions and the relationship between pDC alteration and HHV-6 reactivation in DRESS patients. Methods: Nine DRESS patients and twelve patients of other drug eruptions (ODE, including five cases of maculopapular eruptions (MPEs), five cases of Stevens–Johnson syndrome, and two cases of fixed drug eruption) were prospectively recruited. Blood samples were collected weekly for 2 consecutive weeks for flow cytometry of pDC, basophil, mDC, and detection of HHV-6 reactivation by serum anti-HHV-6 immunoglobulin G, or whole blood HHV-6 viral DNA by quantitative polymerase chain reaction. Results: The HHV-6 reactivation was exclusively seen in DRESS, and the pDC levels decreased in DRESS compared with ODE (P = 0.002) and (MPE, P = 0.021), with the timing of such decrease preceding HHV-6 reactivation. Conclusion: The decrease of pDC levels is significantly more common in DRESS patients and occurs before HHV-6 reactivation. The chronological sequence implies that the decrease of pDC may be crucial in the pathogenesis of viral reactivation.
  - 2,433 289
Aortic stiffness in hidradenitis suppurativa: A case-control study
Emine Tugba Alatas, Murat Biteker, Omer Dogan Alatas
October-December 2021, 39(4):182-185
Background: Although increased aortic stiffness has been observed in chronic inflammatory skin diseases, it has not been examined in patients with hidradenitis suppurativa (HS). Objectives: This study aimed to compare aortic stiffness among HS patients and non-HS controls and to investigate the relation between aortic stiffness and disease severity in HS. Methods: Thirty-eight HS patients, and 76 age- and sex-matched controls were studied. Patients who had diabetes, cardiovascular diseases, chronic kidney disease, or other inflammatory conditions were excluded. Aortic stiffness was measured by transthoracic echocardiography. Disease severity and activity were assessed using Hurley stage, and physician global assessment (PGA) score, respectively. Severe disease was defined as Hurley stage III, or PGA scores ≥3. Results: The patients with HS had increased aortic stiffness determined by decreased strain and distensibility compared to control group patients. A significant negative correlation was found between aortic stiffness indices and high-sensitivity C-reactive protein, duration of the disease, Hurley stage, and PGA score. Multivariate analysis revealed the aortic strain and aortic distensibility were predictors of severe disease for Hurley stage III. Conclusion: Aortic stiffness is increased and associated with the severity of the disease in patients with HS.
  - 2,000 226
Comparison of 1550-nm nonablative fractional laser versus 755-nm picosecond laser with diffractive lens array for atrophic facial acne scars in asian skin: A prospective randomized split-face clinical study
Mao-Ying Lin, Sindy Hu, Chrang-Shi Lin, Wen-Hung Chung
October-December 2021, 39(4):186-191
Background: Nonablative lasers are popular alternatives for atrophic acne scar treatment in Asia. Objectives: We aimed to compare the efficacy and safety between 1550-nm nonablative fractional laser (NAFL) and 755-nm picosecond laser with diffractive lens array (DLA) in Asian patients. Methods: Twenty-three patients with atrophic acne scars received three sessions of split-face treatment with 1550-nm NAFL on one side and 755-nm picosecond laser with DLA on the other side. Sessions were applied at 8-week interval. Blinded dermatologists assessed efficacy through baseline and follow-up photographs. Results: A greater improvement in atrophic facial acne scars was observed on the 1550-nm NAFL side than on the 755-nm picosecond laser side (P < 0.05). Pain was significantly more severe on the 1550-nm NAFL side than the 755-nm picosecond laser side (P < 0.05). Adverse effects on the 1550-nm NAFL side included prolonged erythema, acneiform eruptions, superficial crusting, and postinflammatory hyperpigmentation. Only transient erythema was observed on the 755-nm picosecond laser side. Conclusion: Although the 1550-nm NAFL showed superior efficacy to the 755-nm picosecond laser with DLA for the treatment of atrophic facial acne scars, the latter was associated with fewer adverse effects and may be the best choice for those who request “little-to-no down-time” treatments.
  - 3,687 291
Interleukin-9 and soluble tumor necrosis factor-like weak inducer of apoptosis in serum and suction blister fluid of nonsegmental vitiligo patients: Relation to disease severity
Amira Abulfotooh Eid, Yasmine Amr Issa, Amira Naser Mohamed, Fairouz Khalil Badran
October-December 2021, 39(4):192-197
Background: Autoimmunity is a key player in nonsegmental vitiligo (NSV). Interleukin-9 (IL-9) and tumor necrosis factor-like weak inducer of apoptosis (TWEAK) are pleiotropic cytokines that are involved in many chronic autoimmune diseases. Objectives: To measure IL-9 and TWEAK in serum and suction blister fluid of NSV patients and study their relation to vitiligo. Methods: Thirty NSV patients and thirty controls were recruited. Following detailed history and clinical examination, the vitiligo area scoring index (VASI) and the vitiligo disease activity score (VIDA) of the patients were calculated. IL-9 and TWEAK were measured in serum of patients and controls and in suction blister fluid of patients. Results: Serum levels of IL-9 and TWEAK were significantly higher in patients than in controls (P < 0.001). Meanwhile, in patients, IL-9 and TWEAK were significantly higher in serum than in blister fluid (P < 0.001). A significant positive correlation of serum IL-9 (P < 0.001) and serum TWEAK (P < 0.001) with VASI was detected. A significant positive correlation between serum IL-9 and TWEAK in patients was also detected (P < 0.001). Blister fluid levels of both cytokines showed no significant correlation with any of the studied parameters. Conclusion: The elevated serum IL-9 and TWEAK in NSV possibly contributes to disease development and influences disease severity. Exploring their potential as possible therapeutic targets is, therefore, recommended.
  - 1,932 189
Author Index

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Keyword Index

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Title Index
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