Dermatologica Sinica

REVIEW ARTICLE
Year
: 2022  |  Volume : 40  |  Issue : 2  |  Page : 78--84

Hints from the skin beneath: Vitiligo in Vogt–Koyanagi–Harada disease


Jo Anne Lim1, Wooi Chiang Tan2, Norazirah Md Nor3 
1 Department of Internal Medicine, School of Medical Sciences, Hospital USM, Universiti Sains Malasia, Kelantan, Malaysia
2 Department of Dermatology, Hospital Pulau Pinang, Penang, Malaysia
3 Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

Correspondence Address:
Dr. Jo Anne Lim
Department of Internal Medicine, School of Medical Sciences, Hospital USM, Universiti Sains Malaysia, Kelantan
Malaysia

Vogt–Koyanagi–Harada disease (VKHD) is a major vision-threatening autoimmune disease. One of its associated features is vitiligo. Little study has been done on the association between vitiligo and the disease activity of VKHD. The authors searched available literature on the relationship between vitiligo and ophthalmic disease activity in VKHD in terms of pathogenesis, clinical presentations, risk factors as well as disease activity. Among the findings is that early treatment of VKHD may be associated with full recovery. The reversal of poliosis and vitiligo is associated with the remission of uveitis, but the reverse does not hold true, whereby the worsening of vitiligo may not reflect the worsening of uveitis. It is also found that there may be an association between immunotherapy and Vogt–Koyanagi–Harada-like disease. In summary, vitiligo is an immune-mediated cutaneous manifestation which may contribute to diagnostic and treatment strategies in VKHD. Future research on genetic differences in vitiligo is still needed and may contribute to specific monitoring and therapeutic approach in this disease.


How to cite this article:
Lim JA, Tan WC, Nor NM. Hints from the skin beneath: Vitiligo in Vogt–Koyanagi–Harada disease.Dermatol Sin 2022;40:78-84


How to cite this URL:
Lim JA, Tan WC, Nor NM. Hints from the skin beneath: Vitiligo in Vogt–Koyanagi–Harada disease. Dermatol Sin [serial online] 2022 [cited 2022 Aug 9 ];40:78-84
Available from: https://www.dermsinica.org/article.asp?issn=1027-8117;year=2022;volume=40;issue=2;spage=78;epage=84;aulast=Lim;type=0