Dermatologica Sinica

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 38  |  Issue : 3  |  Page : 159--165

Association of atopic dermatitis with inflammatory bowel disease: A systematic review and meta-analysis


Chi-Hui Wang1, Yun Fu2, Ching-Chi Chi3 
1 Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan; Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan
2 Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan
3 Department of Dermatology, Chang Gung Memorial Hospital, Linkou; College of Medicine, Chang Gung University, Taoyuan, Taiwan

Correspondence Address:
Prof. Ching-Chi Chi
Department of Dermatology, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Guishan, Taoyuan 33305
Taiwan

Background: Altered microbiota of the gastrointestinal tract have been implicated in both atopic dermatitis (AD) and inflammatory bowel disease (IBD). However, the relationship between AD and IBD has been unclear. Objectives: The objective of this study was to systemically assess the evidence on the association of AD with IBD. Methods: We conducted a systematic review and meta-analysis of observational studies on the association of AD with IBD. We searched MEDLINE, Embase, CENTRAL, Web of Science, and Airiti Library from inception to May 24, 2019, for relevant studies. The outcomes were the odds and risk of Crohn's disease (CD) and ulcerative colitis (UC) in patients with AD. Results: We included five case–control studies and one cohort study. We identified significant associations of AD with prevalent CD (odds ratio [OR]: 1.55, 95% confidence interval [CI]: 1.11–2.15) and UC (OR: 2.49, 95% CI: 1.04–5.98). One Danish cohort study found no increased risk for incident CD (hazard ratio [HR]: 0.69, 95% CI: 0.34–1.30) and UC (HR: 0.94, 95% CI: 0.61–1.43) in patients with AD. Conclusion: The current limited evidence supports an association of AD with prevalent IBD. Digestive symptoms in patients with AD, for example, chronic diarrhea and abdominal pain, shall not be overlooked, and gastroenterology counseling may be needed.


How to cite this article:
Wang CH, Fu Y, Chi CC. Association of atopic dermatitis with inflammatory bowel disease: A systematic review and meta-analysis.Dermatol Sin 2020;38:159-165


How to cite this URL:
Wang CH, Fu Y, Chi CC. Association of atopic dermatitis with inflammatory bowel disease: A systematic review and meta-analysis. Dermatol Sin [serial online] 2020 [cited 2022 Jul 7 ];38:159-165
Available from: https://www.dermsinica.org/article.asp?issn=1027-8117;year=2020;volume=38;issue=3;spage=159;epage=165;aulast=Wang;type=0