Dermatologica Sinica

CASE REPORT
Year
: 2019  |  Volume : 37  |  Issue : 4  |  Page : 213--216

Graft-versus-host disease after orthotopic liver transplantation: A case report and review of the literature


Wei-Ti Chen1, Tseng-Tong Kuo2, Kang-Ling Kuo2, Ching-Sheng Yang2 
1 Department of Dermatology, Chang Gung Memorial Hospital, Keelung; College of Medicine, Chang Gung University, Taoyuan, Taiwan
2 Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan

Correspondence Address:
Dr. Ching-Sheng Yang
Department of Dermatology, Chang Gung Memorial Hospital, No. 5 Fusing St., Taoyuan 333
Taiwan

Graft-versus-host disease (GVHD) after liver transplantation (LT) is a rare complication with high mortality and is clinically characterized by fever, skin rash, and diarrhea. The clinical manifestations of GVHD after LT are nonspecific and may resemble viral infection or adverse drug reaction, posing a diagnostic and therapeutic challenge. We report a 60-year-old male who presented with generalized erythematous to violaceous macules and papules accompanied by fever and diarrhea after orthotopic LT. A skin biopsy and human leukocyte antigen typing of peripheral blood confirmed a Grade 2 GVHD. Clinical manifestations and diagnosis of GVHD following LT are discussed. While potentially under-recognized, clinicians should be aware of this rare but potentially fatal complication, as prompt intervention may improve outcomes in LT.


How to cite this article:
Chen WT, Kuo TT, Kuo KL, Yang CS. Graft-versus-host disease after orthotopic liver transplantation: A case report and review of the literature.Dermatol Sin 2019;37:213-216


How to cite this URL:
Chen WT, Kuo TT, Kuo KL, Yang CS. Graft-versus-host disease after orthotopic liver transplantation: A case report and review of the literature. Dermatol Sin [serial online] 2019 [cited 2022 Aug 18 ];37:213-216
Available from: https://www.dermsinica.org/article.asp?issn=1027-8117;year=2019;volume=37;issue=4;spage=213;epage=216;aulast=Chen;type=0