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REVIEW ARTICLE
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Skin microbiome in acne vulgaris, skin aging, and rosacea: An evidence-based review


1 Department of Dermatology, Taichung Veterans General Hospital, Taichung; Graduate Institute of Clinical Medicine, National Yang Ming Chiao Tung University, College of Medicine, Taipei, Taiwan
2 Department of Dermatology, Taichung Veterans General Hospital; College of Medicine, National Chung Hsing University, Taichung, Taiwan

Correspondence Address:
Yi-Ju Chen,
Department of Dermatology, Taichung Veterans General Hospital, No. 1650, Section 4, Taiwan Blvd., Taichung 407; College of Medicine, National Chung Hsing University, Taichung
Taiwan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ds.ds_28_22

The goal of this systematic review was to explore emerging perspectives on the role of skin microbiota in acne vulgaris, skin aging, and rosacea. We searched the literature for published clinical trials, randomized controlled trials, cross-sectional studies, and cohort studies, both experimental and observational, whose primary main purpose was to ascertain the associations between the skin microbiome and chronic skin disease, acne vulgaris, rosacea, and skin aging, using the Embase and PubMed databases. Fifty-one relevant published articles were identified for systematic review (up to December 2021). The possible roles of the skin microbiome in these skin diseases were explored to shed light on its development and to identify potential therapeutic targets for treatment. However, the mechanisms of microbial interaction in these diseases are still under-studied. The results of this evidence-based review suggest that it may be possible to develop individualized therapies targeting the pathogenic strains within the skin microbiome involved in these diseases. This alternative therapeutic approach, involving modifications of the microbiome, may form the basis of the next generation of treatment, known collectively as “ecobiological” anti-inflammatory therapies.


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