• Users Online: 188
  • Print this page
  • Email this page
  • Email this page
  • Email this page
  • Email this page
REVIEW ARTICLE
Year : 2022  |  Volume : 40  |  Issue : 2  |  Page : 78-84

Hints from the skin beneath: Vitiligo in Vogt–Koyanagi–Harada disease


1 Department of Internal Medicine, School of Medical Sciences, Hospital USM, Universiti Sains Malasia, Kelantan, Malaysia
2 Department of Dermatology, Hospital Pulau Pinang, Penang, Malaysia
3 Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

Correspondence Address:
Dr. Jo Anne Lim
Department of Internal Medicine, School of Medical Sciences, Hospital USM, Universiti Sains Malaysia, Kelantan
Malaysia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ds.ds_23_22

Rights and Permissions

Vogt–Koyanagi–Harada disease (VKHD) is a major vision-threatening autoimmune disease. One of its associated features is vitiligo. Little study has been done on the association between vitiligo and the disease activity of VKHD. The authors searched available literature on the relationship between vitiligo and ophthalmic disease activity in VKHD in terms of pathogenesis, clinical presentations, risk factors as well as disease activity. Among the findings is that early treatment of VKHD may be associated with full recovery. The reversal of poliosis and vitiligo is associated with the remission of uveitis, but the reverse does not hold true, whereby the worsening of vitiligo may not reflect the worsening of uveitis. It is also found that there may be an association between immunotherapy and Vogt–Koyanagi–Harada-like disease. In summary, vitiligo is an immune-mediated cutaneous manifestation which may contribute to diagnostic and treatment strategies in VKHD. Future research on genetic differences in vitiligo is still needed and may contribute to specific monitoring and therapeutic approach in this disease.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1483    
    Printed42    
    Emailed0    
    PDF Downloaded136    
    Comments [Add]    

Recommend this journal