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Year : 2019  |  Volume : 37  |  Issue : 4  |  Page : 213-216

Graft-versus-host disease after orthotopic liver transplantation: A case report and review of the literature

1 Department of Dermatology, Chang Gung Memorial Hospital, Keelung; College of Medicine, Chang Gung University, Taoyuan, Taiwan
2 Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan

Correspondence Address:
Dr. Ching-Sheng Yang
Department of Dermatology, Chang Gung Memorial Hospital, No. 5 Fusing St., Taoyuan 333
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ds.ds_2_19

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Graft-versus-host disease (GVHD) after liver transplantation (LT) is a rare complication with high mortality and is clinically characterized by fever, skin rash, and diarrhea. The clinical manifestations of GVHD after LT are nonspecific and may resemble viral infection or adverse drug reaction, posing a diagnostic and therapeutic challenge. We report a 60-year-old male who presented with generalized erythematous to violaceous macules and papules accompanied by fever and diarrhea after orthotopic LT. A skin biopsy and human leukocyte antigen typing of peripheral blood confirmed a Grade 2 GVHD. Clinical manifestations and diagnosis of GVHD following LT are discussed. While potentially under-recognized, clinicians should be aware of this rare but potentially fatal complication, as prompt intervention may improve outcomes in LT.

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