| CASE REPORT |
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| Year : 2019 | Volume
: 37
| Issue : 3 | Page : 166-169 |
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A case of pretibial myxedema associated with hypothyroidism and thyroid-stimulating hormone receptor antibodies
Sang Yong Oh1, Han Kyoung Cho2, Yoon Yang Jung3, Min-Kyung Lee4
1 Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Gyeonggi-do, Republic of Korea
2 Department of Dermatology, Myongji Hospital, Hanyang University College of Medicine, Gyeonggi-do, Republic of Korea
3 Department of Pathology, Myongji Hospital, Hanyang University College of Medicine, Gyeonggi-do, Republic of Korea
4 Department of Internal Medicine, Division of Endocrinology and Metabolism, Myongji Hospital, Hanyang University College of Medicine, Gyeonggi-do, Republic of Korea
Correspondence Address:
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/ds.ds_51_18
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Pretibial myxedema (PTM) is an infiltrative dermopathy seen in Graves' disease. It is also infrequently associated with hypothyroidism. Here, we describe a rare case of PTM with hypothyroidism in which thyroid-stimulating hormone receptor antibodies were found. An 82-year-old female presented with a 1-year history of a large pruritic plaque which was present over both her legs and feet. Histopathology of a skin biopsy showed markedly increased dermal mucin. These changes were suggestive of PTM. This case provides evidence that an autoimmune mechanism could play a central pathogenetic role in such cutaneous manifestations.
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