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Year : 2019  |  Volume : 37  |  Issue : 2  |  Page : 86-89

Toxic epidermal necrolysis in an infant induced by drug intake through breast milk

1 Department of Dermatology, Changhua Christian Hospital, Changhua, Taiwan
2 Department of Pediatrics, Changhua Christian Hospital, Changhua, Taiwan
3 Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan
4 Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Taipei, Linkou and Keelung; College of Medicine, Chang Gung University; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan
5 Department of Dermatology, Changhua Christian Hospital, Changhua; School of Medicine, Chung Shan Medical University, Taichung; Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan City, Taiwan

Correspondence Address:
Dr. Tsu-Man Chiu
Department of Dermatology, Changhua Christian Hospital, No. 135 Nanxiao Street, Changhua City, Changhua County 500
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ds.ds_12_18

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Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis(TEN) are life-threatening severe cutaneous adverse drug reactions, and SJS/TEN in infancy is rare. Here, we present a case of a 4-month-old infant with generalized exanthema, flaccid blisters, and mucosal erosions. He was diagnosed with TEN within 2days using a granulysin quick screen test and subsequently verified with histopathologic findings. Transmission of cephalexin through breastfeeding was suspected to be a possible cause based on drug history, breastfeeding history, and lymphocyte transformation test. The patient survived with only skin hyperpigmentation remaining.

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